mp3®

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  • Tissue origin :
    Cortico-cancellous heterologous bone mix
  • Tissue collagen :
    Preserved plus an additional 10% collagen gel
  • Physical form :
    Pre-hydrated granules and collagen gel
  • Composition :
    90% granulated mix, 10% collagen gel
  • Granulometry :
    600-1000 µm
    1000-2000 µm
  • Re-entry time :
    About 5 months
  • Packaging :
    Syringe: 0.5 cc, 1.0 cc, 3 x 0.25 cc, 3 x 0.5 cc, 3 x 1.0 cc
    Wide tip syringe: 2.0 cc
  • Product codes :
    600-1000 µm
    A3095FS | 1 Syringe | 0.5 cc | Porcine
    A3095FE | 1 Syringe | 0.5 cc | Equine
    A3005FS | 1 Syringe | 1.0 cc | Porcine
    A3005FE | 1 Syringe | 1.0 cc | Equine
    A3075FS | 3 Syringes | 3x0.25 cc | Porcine
    A3015FS | 3 Syringes | 3x0.5 cc | Porcine
    A3015FE | 3 Syringes | 3x0.5 cc | Equine
    A3030FS | 3 Syringes | 3x1.0 cc | Porcine
    A3030FE | 3 Syringes | 3x1.0 cc | Equine
    A3010FS | 1 Wide tip syringe | 2.0 cc | Porcine
    A3010FE | 1 Wide tip syringe | 2.0 cc | Equine
    1000-2000 µm
    A3210FS | 1 Wide tip syringe | 2.0 cc | Porcine
    A3210FE | 1 Wide tip syringe | 2.0 cc | Equine
  • GMDN code : 46425
Characteristics
Heterologous origin biomaterial made of 600-1000 µm or 1000-2000 µm pre-hydrated collagenated cortico-cancellous granules, properly mixed with collagen gel. Thus, it is possible both skipping the hydration phase and decreasing the risk of accidental exposure of the material to pathogens during manipulation and grafting phases; furthermore, the syringe is flexible and ideal to simplify grafting in the receiving site.
The granules are endowed with characteristics very similar to human mineral bone, and can be used as an alternative to autologous bone.
Their natural micro-porous consistency facilitates new bone tissue formation(1) in defect sites and accelerates the regeneration process.
Gradually resorbable(2,3), it preserves the original graft shape and volume (osteoconductive property)(4,5). Moreover, thanks to its collagen content, the product facilitates blood clotting and the subsequent invasion of repairing and regenerative cells.
Handling
mp3® is available in ready-to-use syringes and can be easily grafted avoiding the hydration and manipulation phases. After adapting the material to the defect shape, it is necessary to remove non-stable residues before proceeding to soft tissue suture. It is recommended to always compact mp3® after grafting to achieve optimal stabilization.
Clinical information
mp3® is a pre-hydrated cortico-cancellous bone mix with 10% collagen gel. It has been developed with this innovative biotechnology and is a “ready-to-use” product. mp3® is commonly used for lateral access maxillary sinus lift(1,6), always in association with Evolution membranes, to cover the antrostomy: the mp3® syringe can be directly applied into the bony window without having to mix the mp3® granules with saline. Due to its collagen gel content, mp3® allows an excellent graft stability while its hydrophilia guarantees quick blood absorption and therefore the necessary graft vascularization. mp3® has also been successfully used in combination with Evolution membranes for alveolar ridge preservation(3,7,8): the application of this biomaterial limits the alveolar ridge width and height reduction that would naturally occur with spontaneous healing, preserving thus the alveolar ridge volume and allowing a correct second stage implant placement.
mp3® has been documented for horizontal augmentation (two wall defects) in combination with autogenous bone blocks or with OsteoBiol® Lamina(9,10): its cortico-cancellous composition allows a progressive resorption of osteoclastic type, and in parallel a similar rate of new bone formation(2). These unique properties allow a very good graft volume preservation(11), a healthy new bony tissue and ultimately, a successful implant rehabilitation.
Bibliography
1 RAMIREZ FERNANDEZ MP, CALVO GUIRADO JL, MATÉ SANCHEZ DE VAL JE, DELGADO RUIZ RA, NEGRI B, BARONA DORADO C
ULTRASTRUCTURAL STUDY BY BACKSCATTERED ELECTRON IMAGING AND ELEMENTAL MICROANALYSIS OF BONE-TO-BIOMATERIAL INTERFACE AND MINERAL DEGRADATION OF PORCINE XENOGRAFTS USED IN MAXILLARY SINUS FLOOR ELEVATION
CLIN ORAL IMPLANTS RES, 2013 MAY;24(5):523-30

2 NANNMARK U, SENNERBY L
THE BONE TISSUE RESPONSES TO PREHYDRATED AND COLLAGENATED CORTICO-CANCELLOUS PORCINE BONE GRAFTS: A STUDY IN RABBIT MAXILLARY DEFECTS
CLIN IMPLANT DENT RELAT RES, 2008 DEC;10(4):264-70

3 GIULIANI A, IEZZI G, MAZZONI S, PIATTELLI A, PERROTTI V, BARONE A
REGENERATIVE PROPERTIES OF COLLAGENATED PORCINE BONE GRAFTS IN HUMAN MAXILLA: DEMONSTRATIVE STUDY OF THE KINETICS BY SYNCHROTRON RADIATION MICROTOMOGRAPHY AND LIGHT MICROSCOPY
CLIN ORAL INVESTIG, 2017 2018 JAN;22(1):505-513

4 SCARANO A, LORUSSO F, RAVERA L, MORTELLARO C, PIATTELLI A
BONE REGENERATION IN ILIAC CRESTAL DEFECTS: AN EXPERIMENTAL STUDY ON SHEEP
BIOMED RES INT, 2016;2016:4086870

5 IEZZI G, PIATTELLI A, GIULIANI A, MANGANO C, BARONE A, MANZON L, DEGIDI M, SCARANO A, FILIPPONE A, PERROTTI V
MOLECULAR, CELLULAR AND PHARMACEUTICAL ASPECTS OF FILLING BIOMATERIALS DURING MAXILLARY SINUS-LIFT PROCEDCURES. PART 2: DETAILED CHARACTERISTICS OF THE MATERIALS
CURR PHARM BIOTECHNOL, 2017, 18, 33-44

6 SILVESTRI M, MARTEGANI P, D'AVENIA F, FARNETI M, CAPRI D, PAOLANTONI G, LANDI L
SIMULTANEOUS SINUS AUGMENTATION WITH IMPLANT PLACEMENT: HISTOMORPHOMETRIC COMPARISON OF TWO DIFFERENT GRAFTING MATERIALS. A MULTICENTER DOUBLE-BLIND PROSPECTIVE RANDOMIZED CONTROLLED CLINICAL TRIAL
INT J ORAL MAXILLOFAC IMPLANTS, 2013 MAR-APR;28(2):543-9

7 BARONE A, BORGIA V, COVANI U, RICCI M, PIATTELLI A, IEZZI G
FLAP VERSUS FLAPLESS PROCEDURE FOR RIDGE PRESERVATION IN ALVEOLAR EXTRACTION SOCKETS: A HISTOLOGICAL EVALUATION IN A RANDOMIZED CLINICAL TRIAL
CLIN ORAL IMPLANTS RES, 2015 JUL;26(7):806-13

8 BARONE A, RICCI M, TONELLI P, SANTINI S, COVANI U
TISSUE CHANGES OF EXTRACTION SOCKETS IN HUMANS: A COMPARISON OF SPONTANEOUS HEALING VS. RIDGE PRESERVATION WITH SECONDARY SOFT TISSUE HEALING
CLIN ORAL IMPLANTS RES, 2013 NOV;24(11):1231-7

9 WACHTEL H, FICKL S, HINZE M, BOLZ W, THALMAIR T
THE BONE LAMINA TECHNIQUE: A NOVEL APPROACH FOR LATERAL RIDGE AUGMENTATION - A CASE SERIES
INT J PERIODONTICS RESTORATIVE DENT, 2013 JUL-AUG;33(4):491-7

10 ROSSI R, RANCITELLI D, POLI PP, RASIA DAL POLO M, NANNMARK U, MAIORANA C
THE USE OF A COLLAGENATED PORCINE CORTICAL LAMINA IN THE RECONSTRUCTION OF ALVEOLAR RIDGE DEFECTS. A CLINICAL AND HISTOLOGICAL STUDY
MINERVA STOMATOL, 2016 OCT;65(5):257-68

11 BARONE A, TOTI P, MENCHINI-FABRIS GB, DERCHI G, MARCONCINI S, COVANI U
EXTRA ORAL DIGITAL SCANNING AND IMAGING SUPERIMPOSITION FOR VOLUME ANALYSIS OF BONE REMODELING AFTER TOOTH EXTRACTION WITH AND WITHOUT 2 TYPES OF PARTICULATE PORCINE MINERAL INSERTION: A RANDOMIZED CONTROLLED TRIAL
CLIN IMPLANT DENT RELAT RES, 2017 AUG;19(4):750-759
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