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The unique technology developed by Tecnoss® preserves collagen and maintains the natural structure of hydroxyapatite, avoiding granule ceramisation, allowing to obtain the Dual-Phase OsteoBiol® bone substitutes.

In vitro studies(1) and histologies on rabbits(2) and humans(3) confirmed that OsteoBiol® collagenated biomaterials show chemotactic action on osteogenic cells.
Other in vitro studies demonstrated that OsteoBiol® collagenated biomaterials facilitate osteoblasts migration(1), promote cellular differentiation(4) into osteogenic cells, facilitate blood clot formation, and favor neo-angiogenesis(5).


Collagen is the most abundant protein in the human body and plays a key role in tissue healing. Several studies proved collagen to be a substrate for platelet aggregation(6), endothelial cell adhesion and neo-vascularization(5). The protein is also involved in facilitating bone marrow stem cell differentiation(7) and stimulating the bone regeneration process(8).

  • 1. Jeanneau C et al. Clin Oral Investig, 2020 Jul;24(7):2321-2329
  • 2. Nannmark U et al. Clin Implant Dent Relat Res, 2008 Dec;10(4):264-7
  • 3. Correia F et al. Materials (Basel), 2021 Jun;14(12):3439
  • 4. Alqutub MN et al. Medicina (Kaunas), 2022 Oct 25;58(11):1518
  • 5. Rombouts C et al. Dent Mater J, 2016 Dec 1;35(6):900-907
  • 6. Roberts DE et al. J Biol Chem, 2004 May ;279(19):19421-30
  • 7. Mizuno M et al.J Cell Physiol, 2000 Aug;184(2):207-13
  • 8. Hirota A et al. Oral Maxillofac Surg, 2020 Sep;24(3):299-308
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