GTO®

The sticky xenograft

The product

GTO® is sticky, gradually resorbable and osteoconductive¹.

Thanks to its high collagen content¹, GTO® allows an excellent rate of new bone formation²⁻⁴, delivering adequate graft volume preservation⁵, healthy new bone tissue and, ultimately, a successful implant rehabilitation²⁻⁶. GTO® is a mixture of heterologous collagenated cortico-cancellous granules and TSV Gel, the component that provides its sticky properties⁷.

Histology illustrating the healing after 4 months from GTO® grafting in human. GTO® Dual-Phase bone granules (*) are almost fully resorbed and replaced by an appropriate amount of newly formed bone (#).

GTO_ISTOLOGIA_PRODOTTI

Courtesy of Dr. Paolo Savadori, Università di Modena e Reggio Emilia, Italy

GTO® is a collagenic sticky biomaterial made of a mix of heterologous bone granules and TSV gel. 

GTO_SEM_PRODOTTI

Source: Politecnico di Torino, Torino, Italy

GTO® is sticky, ready-to-use, pre-hydrated, adaptable to the conformation of the defect and stable once grafted. 

Dentist

Why choosing GTO®?

Bone defect conformation varies among patients. GTO® is a Dual-Phase sticky xenograft characterised by high adaptability to the recipient site and high stability once grafted. GTO® allows adequate new bone formation²⁻⁴ and socket volume preservation when used for GBR⁵ in post-extractive sockets with delayed implant placement, even in the case of compromised post-extractive sockets. In combination with OsteoBiol® Lamina®, GTO® can also be the appropriate choice for the treatment of horizontal defects⁴ (i.e. knife-edge ridges). Thanks to its stickiness and ease of handling, GTO® can be used to regenerate bone around peri-implant dehiscences⁵.

handle-gto

How to handle GTO®

GTO® is easily adaptable to any bone defect. It is ready-to-use, pre-hydrated and remains stable into the defect site. Thus, clinicians can skip the hydration step with saline or blood, saving time and decreasing the risk of accidental exposure to pathogens.

References
  1. Jeanneau C et al. Materials (Basel), 2024 Jan 27;17(3):625
  2. Canullo L et al. J Dent, 2024 Nov;150:105337
  3. Passarelli PC et al. Am J Dent, 2024 Sept;37(SIA):9A-12A
  4. Lopez MA et al. Am J Dent, 2024 Sept;37(SIA):41A-44A
  5. Menini M et al. Dent J (Basel), 2024 Jun 27;12(7):198
  6. Passarelli PC et al. Am J Dent, 2024 Sept;37(SIA):4A-8A
  7. Taniguchi Z et al. Int J Oral Maxillofac Implants, 2024 Oct 4;0(0):1-28
     
GTO - Packaging
gto 7RB08101.jpg
gto 7RB08119.jpg
gto HANDLING AL CONTRARIO00003.jpg
Technical specifications

Description: 

  • Collagenic bone mix granules pre-hydrated with a thermosensitive copolymer
  • Pre-hydrated granules and TSV Gel
  • Heterologous bone mix
Porcine origin
Codes Size Type Granulometry Re-entry time
MU0005S 0,5 cc 1 Syringe 600-1000 μm 5 Months
MU0020S 2,0 cc 1 Wide tip syringe 600-1000 μm 5 Months
Equine origin
Codes Size Type Granulometry Re-entry tyme
MU0005E 0,5 cc 1 Syringe 600-1000 μm 5 Months
MU0020E 2,0 cc 1 Wide tip syringe 600-1000 μm 5 Months

Clinical cases

Lateralsinuspack_cover.jpg

Lateral sinus pack and crestal bone into bone technique

Dr. Michele Antonio Lopez

GTO® | Evolution | Lamina®

Horizontal augmentation

Selected bibliography

Open Access

Investigation of the extent of post-extraction bone contraction and bone remodeling after 4 months. A prospective pilot study

J Dent 2024 Nov:150:105337

Canullo L, Savadori P, Triestino A, Pesce P, Sora V, Caponio VCA, Mangano F, Menini M
Copyrighted

On the use of a sticky bone substitute in the presence of a ruptured Schneider membrane during sinus lift procedures - An experimental within-rabbit study

Int J Oral Maxillofac Implants, 2024 Oct 4;0(0):1-28

Taniguchi Z, Esposito M, Xavier SP, Silva ER, Botticelli D, Buti J, Baba S
Open Access

The added value of a collagenated thermosensitive bone substitute as a scaffold for bone regeneration

Materials, 2024 Jan 27;17(3):625

Jeanneau C, Catherine J-H, Giraud T, Lan R, About I
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