
Evolution
Evolution
The product
Evolution collagen membranes originate from xenogenic pericardium and peritoneum.
The membrane structure made of dense collagen fibres of high consistency and resistance makes it a valid choice to protect and stabilize the bone graft in most surgical procedures. These membranes are gradually resorbable¹ and showed great resistance to degradation in in vitro tests²⁻⁴.
Histology illustrating the healing after 2 weeks from Gen-Os® (*) and Evolution grafting in rabbits.

Courtesy of Prof. Daniele Botticelli, Scientific Director of ARDEC Academy, Italy
Evolution membranes originate from equine pericardium and porcine peritoneum tissue.

Source: Politenico di Torino, Torino, Italy.
Evolution membranes are ready to use and are the appropriate choice to stabilise the graft and avoid its contamination.

Why choosing Evolution?
Graft protection against bacteria and food contamination is necessary to allow hard and soft tissue healing. Thanks to their high consistency, resistance to degradation⁴ and stretchability, Evolution collagen membranes are valid solutions to maintain the bone graft stable and isolated thus reducing the risk of complications⁵⁻¹⁰,¹¹⁻¹².The structure made of dense collagen fibres³ and the appropriate gradual degradation rate prevents the infection from bacteria, thus allowing to leave the membrane exposed⁶ when treating post-extractive sockets in the molar and premolar regions.
In addition, Evolution collagen membranes allow second-intention soft tissue healing⁶ allowing adequate new bone formation⁵⁻¹⁰. More than 25 years of clinical and scientific evidence prove that Evolution collagen membranes can be used in post-extraction sockets to protect the graft⁵⁻⁶, in lateral access sinus lift to protect both the antrostomy and the sinus membrane⁷, to stabile the graft around peri-implant lesions⁸, periodontal⁹ defects, and vertical defects¹⁰.

How to handle Evolution
The collagen membrane can be shaped with sterile scissors until the desired size is reached; unless the grafting site is already bleeding, the membrane should be hydrated with physiological solution. Once it acquires the desired plasticity, it must be adapted to the grafting site. In case of accidental exposure, the dense collagenic matrix of Evolution protects the graft from infection; the membrane itself will also not be infected, allowing second-intention healing⁵.
References
- Nannmark U et al. Clin Implant Dent Relat Res, 2008 Dec;10(4):264-70
- Toledano M et al. Polymers (Basel), 2020 Jun 4;12(6):1290
- Osorio R et al. Polymers (Basel), 2022 Aug 11;14(16):3274
- Vallecillo-Rivas M et al. Polymers (Basel), 2021 Sep 5;13(17):3007
- Barone A et al. Clin Oral Implants Res, 2015 Jul;26(7):806-13
- Barone A et al. J Periodontol, 2014 Jan;85(1):14-23
- Scarano A et al. Clin Implant Dent Relat Res, 2011 Mar;13(1):13-8
- Barone A et al. Clin Implant Dent Relat Res, 2016 Dec;18(6):1103-1112
- Esposito M et al. Eur J Oral Implantol, 2015 Autumn;8(3):233-44
- Felice P et al. Int J Periodontics Restorative Dent, 2013 Mar-Apr;33(2):159-66
- Iida T et al. Clin Oral Implants Res, 2017 Dec;28(12):1567-1576
- Hirota A et al. Int J Implant Dent, 2019 Aug 19;5(1):31
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